{"id":859,"date":"2015-11-27T12:45:00","date_gmt":"2015-11-27T01:45:00","guid":{"rendered":"https:\/\/www.athero.org.au\/fh\/what-is-familial-hypercholesterolaemia-fh\/"},"modified":"2015-11-30T12:19:19","modified_gmt":"2015-11-30T01:19:19","slug":"what-is-familial-hypercholesterolaemia-fh","status":"publish","type":"page","link":"https:\/\/www.athero.org.au\/fh\/health-professionals\/what-is-familial-hypercholesterolaemia-fh\/","title":{"rendered":"What is Familial Hypercholesterolaemia (FH)?"},"content":{"rendered":"<ul>\n<li>Familial Hypercholesterolaemia (FH) is a disorder of cholesterol metabolism.<\/li>\n<\/ul>\n<ul>\n<li>FH has an autosomal dominant mode of inheritance and is the most common and serious genetic disorder of lipid metabolism resulting in severe elevations of blood cholesterol levels.<\/li>\n<\/ul>\n<ul>\n<li>Hypercholesterolaemia is present from birth and causes early coronary heart disease (CHD) due to atherosclerosis.<\/li>\n<\/ul>\n<ul>\n<li>FH is caused by mutations in the gene for the receptor for low density lipoprotein (LDL) which controls blood cholesterol levels.<\/li>\n<\/ul>\n<ul>\n<li>Heterozygous FH (HeFH) occurs in approximately 1 in 300 \u2013 500 individuals.<\/li>\n<\/ul>\n<ul>\n<li>Prevalence\u00a0may be\u00a0higher in Afrikaners (1 in 100), Christian Lebanese (1 in 85), South African Ashkenazi Jews (1 in 67), Tunisian (1 in 165) and French Canadian (1 in 270) populations owing to founder effect.<\/li>\n<\/ul>\n<ul>\n<li>Homozygous FH (HoFH) occurs in approximately 1 in a 1,000,000 individuals but may be as frequent as 1 in 160,000 \u2013 300,000 individuals.<\/li>\n<\/ul>\n<ul>\n<li>Patients with HoFH and severe HeFH (mimics HoFH) have markedly elevated circulating levels of LDL cholesterol (untreated LDL cholesterol &gt;13 mmol\/L or treated LDL cholesterol \u2265 8 mmol\/L) and accelerated premature atherosclerotic cardiovascular disease (ACVD).<\/li>\n<\/ul>\n<ul>\n<li>HoFH is rare and life-threatening. These patients need urgent:<\/li>\n<\/ul>\n<ul>\n<ul>\n<li>referral for specialist care<\/li>\n<li>initiation of diet and cholesterol-lowering drug therapy.<\/li>\n<\/ul>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Familial Hypercholesterolaemia (FH) is a disorder of cholesterol metabolism. FH has an autosomal dominant mode of inheritance and is the most common and serious genetic disorder of lipid metabolism resulting in severe elevations of blood cholesterol levels. Hypercholesterolaemia is present from birth and causes early coronary heart disease (CHD) due to atherosclerosis. FH is caused &hellip; <a href=\"https:\/\/www.athero.org.au\/fh\/health-professionals\/what-is-familial-hypercholesterolaemia-fh\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">What is Familial Hypercholesterolaemia (FH)?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":858,"menu_order":320,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_links_to":"","_links_to_target":""},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What is Familial Hypercholesterolaemia (FH)? - FH Australasia Network<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.athero.org.au\/fh\/health-professionals\/what-is-familial-hypercholesterolaemia-fh\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is Familial Hypercholesterolaemia (FH)? - FH Australasia Network\" \/>\n<meta property=\"og:description\" content=\"Familial Hypercholesterolaemia (FH) is a disorder of cholesterol metabolism. FH has an autosomal dominant mode of inheritance and is the most common and serious genetic disorder of lipid metabolism resulting in severe elevations of blood cholesterol levels. Hypercholesterolaemia is present from birth and causes early coronary heart disease (CHD) due to atherosclerosis. 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FH has an autosomal dominant mode of inheritance and is the most common and serious genetic disorder of lipid metabolism resulting in severe elevations of blood cholesterol levels. Hypercholesterolaemia is present from birth and causes early coronary heart disease (CHD) due to atherosclerosis. 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