AAS Quarterly E-Newsletter

December 2007

 

 

Message from the editor

Seasons’ Greetings to you all! As highlighted in David Sullivan’s first President’s Report, it has been a significant year for our society no better illustrated by the highly successful Annual Scientific Meeting held in the very picturesque Fremantle, Trevor Mori and the rest of the WA Committee have continued the tradition of raising the bar for the following year’s Organising Committee. In our continuing series of articles that highlight the research achievements of AAS members, Peter Clifton provides an update of the CSIRO Clinical Nutrition Unit.

Cheers,

David van Reyk

 

 

 

President's Report

This report provides an opportunity to sincerely thank the stalwart group in Western Australia for several recent major tasks they have successfully undertaken on behalf of the Society. Firstly, the Annual Scientific Meeting in Fremantle was a triumph in every respect: great venue, excellent faculty, wonderful scientific content and a timely opportunity to pay tribute to Trevor Redgrave for his extensive contributions to our field of endeavour. I am sure we are all extremely grateful towards Trevor Mori, Gerald Watts, Anne Barden, John Burnett, Hugh Barrett, Dick Chan and Kevin Croft for organising such a successful event.

 

The meeting also provided an opportunity for interstate visitors to learn about the excellent progress being made in Western Australia in the management of Familial Hypercholesterolaemia. The FH Subcommittee was briefed on local initiatives which will assume national importance over the next 3 years. The initial period coincides with Gerald Watts’ chairmanship of the FH Subcommittee, henceforth to be known as FH-AAS. One of the early initiatives will be a meeting with the Chairman of HEART-UK during his forthcoming visit to Australia. This will provide an excellent opportunity for exchange of ideas, and it is anticipated that the outcomes will be reported in the next newsletter.

 

Finally, the Fremantle meeting provided a useful environment to discuss the Society’s educational aspirations with industry partners. Peter Jones generously shared his experiences as past President of the National Lipid Association in the United States, and we anticipate close links with this organisation. The discussions brought us closer to the point where we can anticipate enhanced educational activities for scientific members and an outreach to clinical colleagues as early as 2008. We will also keep members informed of these developments in future newsletters. The successful negotiation of the “Roundtable” that underpins these initiatives is one of several important objectives that Gerald Watts achieved during his extraordinarily productive Presidency. Whilst I would like to sincerely thank him on our behalf, I can assure you of his continued input as Past President and Chairman of FH-AAS.

 

May I wish all members a well-earned rest during the festive season

 

David Sullivan

 

 

 Article – Clinical Nutrition Unit, CSIRO Human Nutrition, Adelaide

The Clinical Nutrition Unit has been performing clinical trials in cardiovascular disease for over 20 years.  Initially under Paul Nestel the group was focused on fatty acids and explored trans fats and polyunsaturated fats particularly but salt, fibre and blood pressure were not ignored. With the increasing incidence of obesity the group turned its attention to obesity and type 2 diabetes and examined the interaction between weight loss and fatty acid composition of the weight loss diet in determining the change in cardiovascular risk factors. This has continued with several examinations of a ketogenic weight loss diet which has shown that saturated fat has a far weaker effect on elevating LDL cholesterol in the context of a very low carbohydrate diet. Finally over the last 8-9 years we have been examining the role of increased protein and lower carbohydrate in a low fat weight loss diet. We have found that this dietary regime leads to greater fat loss at 12 months, lowers triglyceride and in hyperinsulinemic women, spares lean body mass. Its effect on LDL cholesterol appears to be neutral compared with high carbohydrate weight loss diets. Results from these trials have been incorporated in 2 publications: the CSIRO Total Well Being Diet Books 1 and 2, which have sold over a million copies and retuned $3.5 million to CSIRO for further research. Current scientific members of the group include Prof. Peter Clifton, A/Prof Manny Noakes, Dr Grant Brinkworth and Dr Jennifer Keogh with support from trial nurses and dieticians as well as skilled laboratory personnel.

 

 

Australian Atherosclerosis Society 2007 Annual Scientific Meeting
23 – 26 October 2007

Maritime Museum, Fremantle, Western Australia

Well the 2007 ASM has come and gone. I was delighted to see so many people attend and present at the meeting. From the feedback I have received it seems all enjoyed the venue and the great Perth weather - at least till Friday lunchtime!! Special thanks to our invited overseas speakers, Prof Frank Sacks and Prof Peter Jones from the USA, and Prof Keith Frayn from the UK. They not only presented state-of-the-art lectures, but also actively participated throughout the meeting and made themselves available to all. Thank you also to the national invited speakers for your contribution. To our loyal sponsors, thanks again and we look forward to your continued partnership with the AAS.

 

It was fitting that the AAS acknowledged Prof Trevor Redgrave. He has made a great contribution to the Society and atherosclerosis research over a period of many years. We wish him well in his retirement.

 

I think all will agree that the standard of our student presentations was outstanding. In particular, congratulations to the award winners, Doris Chan (AAS Young Investigator Award), Khemanganee Liyanage (Best Oral Student Award) and Shane Antao (Best Poster Student Award).

 

Once again many thanks to all that made the meeting so successful. See you in Sydney in 2008.

 

Trevor Mori

Chairman of the Local Organising Committee

 

 

 

Trevor Redgrave (second from the left) was recognised by AAS for his outstanding and extensive contributions to atherosclerosis research

 

 

Professor Frank Sacks (right) chats with AAS Treasure Jeffrey Cohn

 

 

Professor Roland Stocker (right) gave this year’s Paul Nestel Lecture

 

The AAS ASM: A Student’s Perspective

The 33rd Annual Scientific Meeting of the Australian Atherosclerosis Society was held in the beautiful and historic port city of Fremantle in Perth, Western Australia.  As in previous years, this year’s meeting was a showcase of the outstanding work by basic and clinical researchers on a wide range of topics including nutrition, metabolism, obesity, inflammation and atherosclerosis from Australia and New Zealand. We also had the privilege of interacting and listening to several stimulating and thought provoking lectures from our distinguished overseas speakers Frank Sacks, Peter Jones and Keith Frayn. A highlight of the meeting was the well-deserved tribute to our very own Trevor Redgrave for his outstanding work and contributions to atherosclerosis research. 

For a young clinical researcher, the meeting provided an excellent opportunity to delve into the world of basis science. It was an avenue to ponder on novel ideas and to foster collaborations with other researchers involved in the study of atherosclerosis and cardiovascular disease. Both the poster and oral presentation sessions were important platforms for encouraging researchers to critically analyse data generated and present in a concise and effective manner.

 

On a personal note, it was indeed an honour to be chosen to speak in the Young Investigator’s session and to present amongst a highly talented group of young researchers. I presented the preliminary findings from my PhD project which looked at the effect of early chronic kidney disease (CKD) on the lipoprotein kinetics of very-low-density lipoprotein (VLDL) subclasses in non-diabetic, non-nephrotic, stage 3 CKD (glomerular filtration rate 30-60 ml/min) subjects without central adiposity. Our data suggest that compared with age- and sex- matched healthy controls, CKD was associated with mild hypertriglyceridaemia due a significant delay in the catabolism of VLDL1 and VLDL2 apolipoprotein (apo) B. We also reported that the fractional catabolic rates of VLDL1 and VLDL2 apoB were significantly correlated with apoC-III concentrations. These kinetic changes suggest an important role of uraemia on apolipoproteins, lipolytic enzymes and VLDL receptors. A better understanding of lipoprotein metabolism in patients with CKD may give better insight to the pathogenesis of atherosclerosis in this population, which is at extremely high risk of cardiovascular disease. Furthermore, these data may assist in improving risk stratification and provide guidance for the tailoring of effective pharmacological therapy. 

 

Lastly, I would like to congratulate the organising committee for putting together a highly successful scientific meeting and social program. We look forward to another stimulating meeting in 2008.

Doris Chan

AAS Young Investigator for 2008

Royal Perth Hospital

 

 

Membership News

If you have not renewed your membership, please click here to visit the Meetings First website and renew online. Alternatively, please click here to download a copy of the paper registration form.

 

 

The Australian Atherosclerosis Society always welcomes new members. Please encourage your students and work colleagues to join the AAS. Remember, that members receive thew following:

-          A monthly email that includes, job opportunities, information on meetings relating to atherosclerosis and regular updates on similar interests.

-          A new quarterly newsletter that will feature different articles each quarter.

-          Discounted rates to attend AAS Annual Scientific Meetings.

-          Networking opportunities and involvement.

-          Opportunity to receive student travel grants and present your research at the Annual Scientific Meeting.

-          Opportunity to apply for AAS Trust travel grants

 

 

Forthcoming Meetings

International Symposium on Chylomicrons in Disease (ISCD) 2008

6-8 March 2008, Alberta, Canada

Please click here for more information on this meeting.

 

International Vascular Biology Meeting 2008

1-5 June 2008, Sydney, Australia

Please click here for more information on this meeting.

 

The 2nd World Congress on Controversies in Diabetes, Obesity and Hypertension (CODHy)

30 October – 2 November 2008, Barcelona, Spain

Please click here for more information on this meeting.

 

Future APSAVD Congresses

The 6th APSAVD Congress will be hosted in Hong Kong from 1-5 October 2008 and will coincide with Chinese National Day (October 1). A fantastic fireworks show on the Harbour near the Convention will be a site to see. To be on the mailing list to receive updates on this meeting, please send your contact details through to apsavd@meetingsfirst.com.au.

 

The 7th APSAVD Congress will be hosted by the Australian Atherosclerosis Society in Australia in 2010.

 

 

E-News

The next E-News will be sent out on 18 January 2008. If there is information you would like to include, please email it to aas@meetingsfirst.com.au by Monday 14 January 2008.

 

Please do not hesitate to contact me if you have any queries.

 

Kind Regards,

 

AAS Secretariat

4/184 Main Street

Lilydale VIC 3140

Phone                    +61 3 9739 7697

Fax                          +61 3 9739 7076

Email                     aas@meetingsfirst.com.au