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AAS E-News
May 2008
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AAS Trust Travel Grant Awardee Report I received an AAS Trust Travel Grant,
which contributed significantly towards my travel expenses to the
Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Annual Conference
2008 held April 16-18, 2008 in Atlanta, GA. I presented two posters at the
ATVB Conference. The first poster was entitled “Dose-dependent effect of
rosuvastatin on very-low density lipoprotein apolipoprotein C-III kinetics in
men with the metabolic syndrome”. The study presented resulted from
collaborations with AstraZeneca (Australia and United Kingdom) and Professor
Paul Nestel at the Baker Heart Research Institute, Melbourne. This study
investigated the dose-dependent effect of rosuvastatin on very-low density
lipoprotein (VLDL) apoC-III kinetics in men with the metabolic syndrome in a
randomized, double blind, three-way crossover placebo-controlled clinical
trial. The kinetics of VLDL apoC-III were measured using a stable isotope
(D3-leucine), gas-chromatography mass spectrometry and multi-compartmental
modelling. The data suggest that rosuvastatin dose-dependently decreased VLDL
apoC-III concentration by a mechanism related to an increase in VLDL apoC-III
fractional catabolic rate (FCR) and a decrease in VLDL apoC-III production
rate (PR). These findings provide a mechanistic explanation for the
triglyceride-lowering effects of rosuvastatin with implications for
cardiovascular risk reduction in the metabolic syndrome. This poster was
short listed and won an ATVB Conference Merit Award for Young
Investigators/New Investigator Travel Award.
The second poster was entitled
“Regulatory effect of atorvastatin and fenofibrate on apolipoprotein C-III
kinetics in the metabolic syndrome”. The study investigated the effect of two
different lipid-lowering agents, atorvastatin and fenofibrate on VLDL
apoC-III kinetics in men with the metabolic syndrome. The data suggest that
atorvastatin and fenofibrate decreased VLDL apoC-III concentration as a
consequence of increased VLDL apoC-III FCR and decreased VLDL apoC-III PR.
These findings may explain one of the lipoprotein-mediated benefits of these
agents on triglyceride concentrations and hence, cardiovascular risk in the
metabolic syndrome. In addition, I presented a talk
at the Lipoprotein Kinetics Satellite Meeting on April 15, 2008 in Atlanta.
The talk was entitled “Dose-dependent effect of rosuvastatin on very-low
density lipoprotein apolipoprotein C-III kinetics in men with the metabolic
syndrome”. The Kinetics Satellite Meeting acts as a platform to discuss
methodological issues related to the performance of metabolic studies and the
application of compartmental modelling to better understand the physiology
and pathophysiology of complex systems. The posters and oral
presentations were very well received, and I obtained valuable feedback and
comments from experts present at the conference. In addition, I met with
Professor Ernst Schaefer (Tufts University) to discuss our collaborative work
on a recently started systems biology project. I also met with Professors
Murray Huff (University of Western Ontario) and Elizabeth Parks (University
of Texas, Southwestern Medical Center), both who continue to provide
informative insights into methodologies associated with performance of
complex metabolic studies. I also had the pleasure of meeting with Professor
Larry Rudel (Wake Forest University) who took significant interest in
discussing the findings of my first poster and suggested potential
collaborative work between his laboratory and our Metabolic Research
Centre. I would like to thank the
Australian Atherosclerosis Society for the funding support provided. Having
the opportunity to apply one’s knowledge and to be challenged and tested in
an international research arena further reinforces and substantiates ones’
desire to progress in research and innovation. Dr Esther Ooi University of Western Australia |
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AAS Annual Scientific Meeting 2008 28 – 31 October 2008 Swiss Grand Hotel Bondi Beach, New South Wales Click here for more
information on this meeting. Put these dates in your diaries now! Close of abstracts 15
August 2008 Close of Early bird registrations 8 September 2008 Close of accommodation bookings 8 September 2008 Conference starts 28
October 2008 |
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AAS and Pfizer
Awareness Campaign Cholesterol fails to break the
ignorance barrier Australian Medicine, Page: 29 Monday, 21 April 2008
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International Atherosclerosis Society Click here to view
the April E-Newsletter. |
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International Vascular Biology Meeting 2008 1-5
June 2008, Sydney, Australia Click here for more
information on this meeting. A reminder to register now for the International Vascular
Biology Meeting (IVBM2008, June 1-5, Sydney). Details of the final Scientific
Programme and how to register for the meeting can be found at www.ivbm2008.com. The 5 day IVBM Scientific Programme features 128 separate
Talks spanning the latest developments in Vascular Biology, through -
7 Plenary Sessions (with 14 confirmed Plenary Speakers) -
18 x 2 hour Symposia Workshops (with 38 confirmed Invited
Speakers and 68 Oral Presentations from submitted Abstracts) -
2 Satellite Symposia (8 Invited Speakers) -
3 separate Poster Sessions |
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Atherothrombosis IVBM Satellite Meeting: The
Disease Continuum 6 – 7 June 2008, Baker Heart Research
Institute, Melbourne Click here for more information on this meeting. |
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XV International Symposium on
Atherosclerosis 14 – 18 June 2009, Boston, Massachusetts, USA Click here for more information on this meeting. |
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ADS-ADEA Annual Scientific Meeting 27 – 29 August 2008,
Melbourne Exhibition and Convention Centre Click here for more
information on this meeting. |
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APSAVD Congress 2008 25 – 28 September 2008 Click here for more information on
this meeting. Call
for abstracts is now open! A late breaking session has been scheduled for
delegates wishing to present their latest clinical trial data in
atherosclerosis and/or metabolic disease research. |
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The 2nd World Congress on Controversies in
Diabetes, Obesity and Hypertension (CODHy) 30
October – 2 November 2008, Barcelona, Spain Click here for more
information on this meeting. |
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E-News The next E-News will be sent out on Monday 16 June
2008. If there is information you would like to include, please email it to aas@meetingsfirst.com.au
by Monday 9 June 2008. Please do
not hesitate to contact m if you have any queries. Kind
Regards, AAS
Secretariat 4/184
Main Street Lilydale VIC 3140 Phone +61
3 9739 7697 Fax +61
3 9739 7076 Email aas@meetingsfirst.com.au |
